The transcription or the expression of a gene(the process by which the DNA sequence is converted into a functional product like protein or RNA) is controlled by the region of the DNA generally present upstream of the gene. This region consists of several short segments(also known as motifs) which act as binding sites to proteins [...]
Archive for the ‘transcription’ Category
Studying the evolution of cis-regulatory elements of co-expressed genes
Posted in cis-regulatory elements, co-expressed genes, transcription on March 20, 2008 | Leave a Comment »
No transcription factories !!
Posted in DNA-protein interactions, RNA POlII, gene regulation, transcription, transcription factory, tagged FISH, RNA pol II, transcription, transcription factory on February 19, 2008 | Leave a Comment »
Last week I blogged on the talk by Peter Fraser where he showed evidence for the existence of transcription factories. He showed pictures as follows to demonstrate the theory of transcription factory.
Fig. 1. Transcription factories are concentrated foci of active RNA polymerase. Immuno-detection of the hyper-phosphorylated form of RNAPII reveals their [...]
Transcription factories
Posted in DNA-protein interactions, gene regulation, transcription, transcription factory on February 7, 2008 | Leave a Comment »
Today we had a very fascinating story by Peter Fraser (from the Babraham Institute, Cambridge), suggesting that genes migrate to specialized sites called transcription factories in the nucleus for transcription. These transcription factories are nothing but discrete foci in the nucleus containing high concentrations of RNA polII(the eukaryotic polymerase responsible for transcription of protein-coding [...]
Transcriptional noise or meaningful RNA
Posted in transcription on July 4, 2007 | Leave a Comment »
Today I read a paper from Genome Research 17:746-759, 2007. The authors have tried to annotate transcript products(RNA) from 399 annotated protein-coding loci which represent 1% of the human genome. Just as a reminder, from a single gene locus a large number of diverse transcripts can be produced, this is majorly through alternative splicing. [...]
